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Crestor® (rosuvastatin calcium)

Crestor (rosuvastatin calcium) is manufactured and marketed by AstraZeneca Pharmaceuticals and is a statin drug; i.e. a medicine that lowers “bad” cholesterol and triglycerides, and raises “good” cholesterol in the blood.

Why is Crestor prescribed?

Crestor is an orally administered, lipid-lowering agent that belongs to a class of drugs called HMG-CoA reductase inhibitors (statins), designed to lower bad cholesterol (LDL) and triglycerides (TG) levels in the blood stream.

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What are the FDA approved uses for Crestor?

In August 2003, the FDA approved Crestor, the latest of six cholesterol reducing drugs called statins. Crestor is approved as an adjunct therapy accompanied by a low-cholesterol diet and exercise program to reduce the overall level of bad cholesterol in the blood stream. It was also touted for raising levels of High-Density Lipoprotein Cholesterol (HDL-C, or good cholesterol) in many cases.

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What are the side effects of Crestor?

Crestor can cause or contribute to causing rhabdomyolysis, a condition in which muscle cells are damaged causing release of myoglobin, which in turn causes kidney damage and can be fatal. Symptoms of rhabdomyolysis include dark or red urine, muscle tenderness, muscle or generalized weakness, muscle stiffness, joint pain, fatigue and, sometimes, seizures.

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Crestor warnings and alerts

Crestor side effects could prove crippling or even deadly – rhabdomyolysis occurs when a large number of skeletal muscle cells die, resulting in the release of a massive amount of muscle protein into the bloodstream. The muscle protein becomes trapped in the kidneys, affecting the filtering process of the kidneys and leading to kidney failure. Related Crestor side effects include serious liver damage and liver death.

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Crestor drug contradictions

Crestor is contraindicated in patients with hypersensitivity to rosuvastatin or to any of the excipients, in patients with active liver disease including unexplained, persistent elevations of serum transaminases and any serum transaminase elevation exceeding 3 x the upper limit of normal (ULN), in patients with severe renal impairment, in patients with myopathy, in patients receiving concomitant ciclosporin, in women during pregnancy and lactation, in women of childbearing potential not using appropriate contraceptive measures, and in Asian patients or patients with Asian ancestry.

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Crestor FAQs

What should I tell my doctor before taking Crestor?

Before starting Crestor, tell your doctor or health care provider about all medical conditions, including:

  • If you are pregnant or planning to become pregnant
  • If you are breast-feeding
  • If you have liver problems
  • If you have kidney problems
  • If you drink alcohol

Also, be sure to tell your health care provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Crestor and certain medicines may interact with each other causing serious side effects.

What drugs affect Crestor?

Do not take Crestor if you are taking:

  • The blood thinner Coumadin
  • Cyclosporine, a medicine with multiple uses, including use after organ transplants or for rheumatoid arthritis and psoriasis
  • Certain types of other medicines that lower cholesterol
  • Antacids.

Can I file a lawsuit if I have suffered damages from taking Crestor?

Possibly. While all medications have certain, anticipated side effects, a drug manufacturer has a duty to inform physicians adequately regarding the known risks associated with its drugs. If a manufacturer fails to do so, it can be held responsible to patients who are injured as the result of inadequate warnings, under a legal theory known as “product liability.” Depending upon the particular circumstances of your case, damages may include recovery for any of the following:

  • Past and future medical expenses
  • Past and future pain and suffering
  • Lost wages
  • Loss of future earning capacity
  • Emotional distress

If you or a loved one has experienced any health problems while taking Crestor, you should contact your doctor immediately. You may also wish to contact an experienced Crestor lawyer to discuss your legal options. As all legal claims are subject to time limits, however, you may risk forfeiture of your right to financial compensation if you delay.

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